巴西专利BR112014019290B1 COMBINED COVER APPLICERS AND METHOD

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专利摘要:
combination cap applicators. The present invention relates to an example of combined cap applicator and protective devices that can be used in combination with one or more cleaning, antimicrobial and/or antiseptic agents to reduce or eliminate contaminants on a surface. according to some embodiments, the disclosure describes that the combined cap applicators may comprise a first and a second cap, where each cap contains an applicator. in some embodiments, the applicator can be coated or infused with a cleaning, antimicrobial, or antiseptic agent for use on a surface.
公开号:BR112014019290B1
申请号:R112014019290-1
申请日:2013-02-04
公开日:2021-06-15
发明作者:Patrick O. Tennican
申请人:Hyprotek, Inc；
IPC主号:

专利说明:

CROSS REFERENCE TO RELATED ORDER
[001] This application claims priority to US Provisional Patent Application No. 13/757,318 filed February 1, 2013 entitled "Combine Cap Applicators" which claims priority to US Provisional Patent Application No. 61/595,635 filed 6 of February 2012 entitled "Antiseptic Applicators and Protective Devices", both of which are hereby incorporated by reference in their entirety. FUNDAMENTALS
[002] Acquired Health Infection (HAI) has been recognized as an important cause of preventable morbidity and mortality. In the United States, HAI annually is responsible for the loss of nearly 99,000 lives and billions of dollars in additional treatment and hospitalization. Klevens, et al., Estimating Health Care-Associated Infection and Deaths in U.S. Hospitals, 2002, Public Health Reports, Vol. 122, p. 160, 2007. Contamination of intravascular catheters, surgical sites, and invasive procedure sites often leads to device removal and replacement, prolonged parenteral antimicrobial therapy, and extended hospitalizations and rehabilitation.
[003] The spread of organisms resistant to various antimicrobials often spread through the hands of health professionals or medical equipment, from a colonized or infected patient to other susceptible patients. Surgical site infections can result from inadequate antiseptic skin preparations. The widespread use of chlorhexidine gluconate (CHG) for routine washing and cleaning of preoperative sites has led to an increased incidence of methicillin-resistant Staphylococcus aureus (MRSA) and CHG in some hospital settings. BRIEF DESCRIPTION OF THE FIGURES
[004] The detailed description is established with reference to the accompanying figures. In the figures, the leftmost digit(s) of a reference number identify(s) the value at which the reference number appears first. The use of the same reference numbers in different figures indicates similar or identical items or functions.
[005] FIGS. 1A and 1B illustrate an example of a combined cap applicator.
[006] FIG. 2 is a flow diagram showing an example process for using a combination cap applicator.
[007] FIG. 3 illustrates an example of a protective cap device.
[008] FIG. 4 illustrates an example foam applicator example of an example combination cap applicator or an example protective device.
[009] FIGS. 5A-5C illustrate various mechanisms for attaching an exemplary combination cap applicator or an exemplary protective device.
[010] FIGS. 6A-6C illustrate various ways of a protective device of the packaging example. DETAILED DESCRIPTION Overview
[011] This disclosure describes medical combination cap applicators and protective cap devices designed to reduce and/or prevent infections. In one embodiment, the disclosure describes an example combined cap applicator. Combination cap applicators may include a removable first cap and a second cap coupled together. The lids are detachable to expose a container or interior cavity within each lid. Each container within each cap, containing a permeable foam applicator material that can be coated or filled with, for example, a cleaning composition, antiseptics or antimicrobials.
[012] In another embodiment, the disclosure describes example protective cap devices for various dose/use vials. The cap device may contain a foam material impregnated with an antimicrobial composition which, upon application of the cap device for a dose/multiple-use vial, bathes the metal ring and elastomeric vial stopper in the composition. antimicrobial. Thereby reducing the bottle and/or preventing the presence of one or more contaminants upon a multiple dose/use. In addition, the foam material is constructed to prevent contamination of the contents of a multi-use/multi-dose vial.
[013] The detailed discussion below begins with a section entitled "Example Antimicrobial Composition", which describes in detail an example antimicrobial composition that may be included in the medical applicators and devices described herein. Next, the disclosure describes the "Example of Combined Cap Applicators". Next, the disclosure describes "Process Example" for using an example of a combination cap applicator. The following sections entitled "Protective Cap Device Example" and "Protective Cap Device Packaging Example" describe in detail several examples of leveling devices for use in various dose/use vials. The disclosure then describes "Other Cover Devices." Finally, the disclosure concludes with a brief "Conclusion".
[014] This summary is provided to present a selection of concepts in a simplified form which are described below in the detailed description. The view is provided for the reader's convenience only and is not intended to limit the scope of the claims nor the process sections. Example of Antimicrobial Composition
[015] In an exemplary embodiment, antimicrobial compositions that may be used in connection with the approaches described herein may include those described in, for example, US Provisional Patent Application No. 61/412,375, filed November 10, 2010 to Tennican et al., which is incorporated herein by reference. For example, antimicrobial compositions can include water (H2O), a strong and toxic chelating agent such as ethylenediaminetetraacetic acid (EDTA) (e.g. disodium EDTA, disodium calcium EDTA, magnesium EDTA, potassium EDTA, gallium EDTA) , or sodium citrate (or acids, salts, derivatives or other forms of EDTA or sodium citrate), a short-chain alcohol-saturated monoalcoholic-saturated alcohol (for example, ethanol with a molecular formula of C2H5OH and an empirical formula of C2H6O) and a small molecule, strong oxidizing agent such as hydrogen peroxide (H2O2). In a specific example, the compositions can consist essentially of water, ethanol, EDTA and hydrogen peroxide. Additional ingredients may include thickeners, gelants, surfactants, foams and/or foam stabilizers. However, in other examples, other antimicrobial compositions can be used in combination with the devices described in the disclosure and applicators.
[016] Antimicrobial compositions can be in a liquid form or a gel form and can be combined with one or more carriers or diluents, depending on the needs of a specific application. For example, if the antimicrobial composition is used as a cleaning agent the antimicrobial composition can be in liquid form. In that case, the concentration of the various constituents may depend, for example, on a desired level of sanitation and/or disinfection, whether the composition is being applied directly to living tissue, or to a medical device, and/or to avoid tissue irritation. so that the makeup will be applied directly or indirectly (eg through a medical device to which the makeup is or was applied).
[017] In addition to providing disinfection at the time of application, antimicrobial compositions can also provide a lasting barrier against contamination. For example, even after volatile substances in the composition (eg water, alcohol, hydrogen peroxide, etc.) have evaporated, the chelating agent may remain on treated surfaces (eg multi-use bottles or cleaning/safety door bottles of the device, stethoscope, fingers, around tissue, etc.) as a barrier that will provide antibacterial, antifungal or sporicidal (eg, prevent spore germination), antiparasitic, spermicide, or spermiostatic (eg, decrease motility sperm) and antiviral qualities. By robbing the environment of components (eg, iron, magnesium and manganese) that are necessary for bacteria, spores, parasites, fungi and viruses to reproduce, the chelating agent provides a lasting defense to contamination even after other constituents of the anti-mimic composition. crobian evaporated. In addition, hydrogen peroxide in antimicrobial compositions can induce a charge on a surface of materials (eg, silicone materials) to which antimicrobial compositions are applied, which makes the materials more resistant to bacteria or other microorganisms.
[018] In some embodiments, the antimicrobial composition described above may also provide a visual indication of contamination when applied to a surface or material, such an indication may allow users to identify and clean surfaces to prevent infection.
[019] The term "about" or "approximate" as used in the context of describing the example antimicrobial composition is to be interpreted to include a reasonable margin of error that would be acceptable and/or known in the art. Example of Combined Cap Applicators
[020] FIGS. 1A and 1B illustrate an exemplary embodiment of a combination cap applicator in which a first cap applicator 100 may be removably coupled to the second cap applicator 102. Exemplary materials for the composition of the first cap 100 and the second cap 102 include, but are not limited to, polypropylene, polyethylene and/or other copolymer materials. The first lid 100 and the second lid 102 may also include a material or agent that is UV protective to preserve the integrity of the antimicrobial composition during storage, transportation, etc. In other embodiments, the first cap 100 and the second cap 102 may include caps as described in US Patent Application No. 13/688,044, filed November 28, 2012 to Tennican et al, entitled "Port and Surface Cleaning Devices and Techniques ”, which is incorporated herein by reference.
[021] FIGS. 1A and 1B illustrate an exemplary embodiment in which both the first cap 100 and the second cap 102 include an applicator material 104 and 106, respectively, disposed within a container or interior cavity of each of the caps, prior to use. When the first cap 100 and the second cap 102 are coupled along the pictorial line 108, the applicator materials 104 and 106 of each protective cap may be in a compressed state. When the first and second caps 100 and 102 are separated from each other, the applicator material 104 and 106 may expand and/or protrude from the interior cavity of each cap for use in cleaning or disinfecting a desired location as illustrated by caps 100 and 102 in FIG. 1B (for example, for disinfecting an intravascular port line, preparing the site for a medical procedure, or the like).
[022] In some embodiments, the applicator material 104 and 106 housed within each cap is a permeable foam or sponge material, which can be coated or impregnated with a cleaning, antimicrobial or antiseptic composition as described in the previous section. Exemplary materials for the composition of applicator material 104 and 106 may include, but are not limited to, starch polymer, cellulosic gel, polyurethane, silicone, silicone rubber, polyethylene, polypropylene, thermoplastic elastomer, or mixtures thereof.
[023] In some embodiments, the applicator material 104 and 106 may include, but are not limited to, different surface treatments (e.g., lamellar, cutting, etc.), surface finishes (e.g., macro, micro, or nanostructures, etc.), and/or contours (eg, rounded, ribbed, raised, fingered, etc.) to provide cleaning and/or washing efficiency. In some embodiments, the applicator material in the first cap may be configured similar to the applicator material in the second cap (e.g., with the same surface treatments, coatings, and/or contours). However, in other embodiments, the applicator material in the first cap may be configured with a different surface treatment, coatings and/or contours than the applicator material in the second cap.
[024] Furthermore, while caps 100 and 102 and the applicator material 104 and 106 are illustrated as being a generally cylindrical body, in other embodiments, the applicator material may take on other shapes and/or sizes. In some embodiments, the applicator material may have a shape substantially similar to the shape of the corresponding lid container. For example, where the container is cylindrical, the applicator can also be cylindrical material.
[025] In some embodiments, the first cap 100 and the second cap 102 may be coupled together (e.g., during manufacturing, packaging, assembly, etc.) by threads, a snap-on flange, a snap-on channel. pressure, a molded feature (for example, the first cap can be custom expressed in one of several shapes that uniquely match the shape of the second cap, allowing a resin or adhesive, for example, to form a peelable seal when the first and second lid are connected), or something like that. In some embodiments, the connection of the first cap 100 to the second cap 102 forms a seal to enclose the antiseptic, antimicrobial or cleaning composition thereon, thus preventing leakage or evaporation.
[026] The first cap 100 can be removed or removed from the second cap 102 by, for example, twisting, pulling, snapping or folding the first cap away from the second cap.
[027] In other modalities, each lid can, in addition, be sealed by a removable protective film or lid on the interior cavity that keeps the applicator material and antiseptic, antimicrobial or cleaning composition in the respective lids. In some embodiments, each applicator material of each protective cap may contain a different cleaning, antimicrobial or antiseptic composition, and/or different concentration of such composition.
[028] In some embodiments, the first cap 100 may include a cap having an applicator material that protrudes from the cap container, while the second cap 102 comprises a cap having applicator material that fully fits within and/or is embedded in a container. on the lid when in use. In that case, the first cap 100 with the material protruding from the applicator can be used to clean a surface (e.g., an intravascular line, valve, or port, an injection site or the like) and the second cap 102 with the applicator material embedded can be used to cover and protect a port, vial, or other component (eg, an intravascular access port, vial, or the like).
[029] In some embodiments, where the first or second cover may be configured to cover and/or protect a surface as described above, each of the first and second cover may have one of several example mechanisms for attaching each cover to the surface, as described below in FIGS. 4C and 5A-5C. Process Example
[030] FIG. 2 illustrates an example process 200 for performing the techniques described above of operating a combination cap applicator. Process 200 is illustrated as a logical flow chart. The order in which the operations are described is not intended to be construed as a limitation, and any number of the operations described may be combined in any order and/or in parallel to implement the process.
[031] In operation 202, a device comprising a removable first cover coupled to a second cover can be obtained. For example, such a device can be any of the combination cap applicator embodiments as described above.
[032] In operation 204, the first cap of the device can be detached from the second cap. In the context of FIG. 1, a user can remove the first cap by twisting, pulling, pulling or folding the first cap 100 away from the second cap 102.
[033] In operation 206, an applicator located in the cavity of the first cap can be applied to a surface. Again, in the context of FIG. 1, applicator 104 can be configured to extend beyond the cavity of the first cap when separated from the second cap. The applicator can be configured with different surface treatments and/or contours for scrubbing, cleaning, or disinfecting a surface (eg, an intravascular line, valve, or port, an injection site, or the like).
[034] Finally, in operation 208, the second cap can be releasably attached to the surface. By attaching the second cap to the surface, the surface can be protected from becoming recontaminated by other environmental contaminants. Protective Cover Device Example
[035] Several example protective cap devices are described here. Example protective cap devices are generally described with reference to FIG. 3-6
[036] FIG. 3 shows an illustration of an example protective cap device 300 that can attach to the neck and exposed to the elastomeric stopper of a multi-use/multi-dose vial ("vial") 302 after the vial is opened. The example protective cap device 300 having a cylindrical cavity that includes a foam insert 304 carrying an antimicrobial composition, such as the antimicrobial composition described in the previous section. The example protective cap device 300 can be placed on a vial to protect the vial from microbial and particulate contamination while the vial is not in use. The example protective device may include covers as described in the previous section.
[037] In the example illustrated in FIG. 3, the outer surface of the protective cap device example 300 is shown to have a specific texture 306 which can assist the user in gripping the protective cap device example. However, the texture of the protective cap device example is not limited to that texture. Furthermore, or alternatively, the example protective cap device 300 can be any color which can, for example, assist the user in quick initial identification of the bottle. For example, a bottle used frequently in an emergency scenario (eg, emergency room, ambulance, etc.) might have a red protective cap. Additionally, or alternatively, the size of the protective cap device example 300 may vary based in part on the vial size. The example of the protective cap device 300 is shown as having a round shape, although alternative shapes are contemplated, such as, for example, a square shape, rectangular shape, oval shape, a polygon shape and the like. Generally, however, an opening of the protective cap device is shaped and sized to accommodate and protect the vial 302.
[038] In some embodiments, the protective cap device example may include a tag area to label the user and/or the placement of an identification tag or barcode tracking.
[039] As shown in FIG. 3, the inner surface within the cavity of the exemplary protective cap device contains a foam insert 304. The foam insert 304, as shown in greater detail in FIG. 4, comprises a foam material having an open cell region 400 around the circumference of the sides of the cylinder and a closed cell region 402 at one or both axial ends of the cylinder. Exemplary materials for applicator material composition 304 include, but are not limited to, starch polymer, cellulosic gel, polyurethane, silicone, silicone rubber, polyethylene, polypropylene, thermoplastic elastomer, or mixtures thereof. The open cell region 400 of the foam insert has a porous structure that allows an antimicrobial composition, such as the antimicrobial composition described above, to be disposed along all or part of the open cell region 400. The cell region Closed 402 of the foam insert has a non-porous structure that is designed to interface with the metal ring and elastomeric stopper on the vial. The closed cell region 402 of the foam insert can provide a barrier and prevent a contaminant from entering the elastomeric vial plug and/or prevent the vial contents from escaping. In addition, the closed cell region prevents substantial amounts of the antimicrobial composition from entering the vial. In some embodiments, the closed cell region may have different surface finishes, treatments, or contours (eg, macro-, micro-, or nanostructures, etc.). to facilitate holding and/or washing the bottle.
[040] FIGS. 4-5C illustrate various example mechanisms for connecting the example protective cap device to a vial. As shown in FIG. 4, the inner surface of the example protective cap device 404 includes threads 406 molded into the inner surface of the cavity. This bonding feature may allow the user to screw, in a twisting motion, the case of protective cap device onto the bottle. In the present modality, the threads can be used to take advantage and act according to the anatomical characteristics of the neck of the bottle.
[041] FIG. 5A illustrates an example protective cap device 500A having a stepped inner surface including a first inner surface 502 and a second inner surface 504, second inner surface 504 having an average diameter smaller than the first inner surface. The first and second inner surfaces 502 and 504 may have diameters chosen to match the outside diameter ("OD") of common vials on the market, the maximum and minimum OD of vials on the market, or based on other criteria. In addition, both the first and second inner surfaces 502 and 504 can be tapered (i.e., have a slope angle θ), so that a diameter of one of the first and second inner surfaces is larger closer to one. opening of the protective cap device example 500A and decreases towards the bottom, closed end of the protective cap device example. A design angle of the first inner surface 502 can be equal to, greater than or less than a design angle of the second inner surface 504. When the capping device example 500A is placed on a vial, the capping device example 500A will slide over the vial until an overdose of the vial contacts and seals against the inner surface of the 500A protective cap device example on the first inner diameter 502 (in the case of a vial with a relatively large OD) or the second inner diameter 504 ( in the case of a bottle with a relatively small OD).
[042] FIGS. 5B and 5C illustrate alternative embodiments of slip fit protective cover devices 500B and 500C, respectively, which have smooth, continuous internal surfaces. Instead of being scaled, as in the embodiment of FIG. 5A, 500B and 500C protective cover devices have smooth, continuous inner surfaces. The inner surfaces of the 500B and 500C protective cap devices are tapered to accommodate vials of mixed OD. However, to accommodate vials having a wide OD range, the θ angle design of the protective cap devices needs to be larger (i.e. a more steep slope) as in the case of the 500B cap device, and/or the device of protective cover needs to be made deeper, as in the case of 500C protective cover device.
[043] In other embodiments, the example protective cap device can be constructed with a flange on the inner surface, at the cavity opening. The inner surface of the case of protective cover device can have a continuous and smooth surface. In this embodiment, the size of the flange may vary depending, in part, on the OD of the vial neck. When the sample cap device in this embodiment is placed over the bottle the flange allows the sample cap to fit over the neck of the bottle.
[044] In still other embodiments, the example of the protective cap device may have internal slits in the cap that runs from the opening of the closed cavity at the end of the example of the protective cap device. The slits can expand only part way through the lid wall such that the lid still provides a seal to prevent contamination of the vial. The internal slits in the case of the protective cap device would allow the cap to expand surrounding a portion of the vial as the example of the protective cap device is slid over the vial.
[045] In yet other embodiments, the protective cap example may have a wire mechanism located in or around the cavity to allow connection with a vial. The wire mechanism can take the form of a spring. As with the example threads 406 in Fig. 4, the wire mechanism may allow a user to twist, tighten, crimp or otherwise securely affix the example cap device securely to the vial. Any of the above-mentioned attachment modalities can be used separately or in conjunction with another to attach the example protective cap device to the vial. Protective Lid Device Packaging Example
[046] Any example of one of the protective cap devices described above may be sterile packaged individually or in multi-device kits in a variety of packaging. Furthermore, the protective cap devices themselves may additionally or alternatively be housed in a package that contains UV protection materials to inhibit degradation of the antimicrobial composition.
[047] FIGS. 6A-6C illustrate three example ways of packing the example of the example protective cap devices described in this document. As shown in FIG. 6A, each protective lid device can be individually sealed in a pouch or package 600 by pressing the protective lid device between several layers of thermoplastic material and sealing the sheets of material to each other around an outer contour of the device by, by. example, ultrasonic welding, microwave welding, thermal bonding, protective cap or the like.
[048] The approach described in FIG. 6A can be extended to simultaneously pack multiple protective cap devices on a strip by means of multiple cap devices between the sheets of thermoplastic material and then sealing the sheets of material together around the outer contours of each. cover devices using any of the sealing methods described above. The result is a strip 602, as illustrated in 6B, containing several individually sealed protective cap devices. Individual protective cap devices may then be dispensed with by cutting between the protective cap devices in strip 602. Alternatively, strip 602 may include perforations or scoring lines between individual protective cap devices in strip 602.
[049] In another embodiment, as seen in FIG. 6C, a package may include a plurality of protective cap devices that have the open end of the cavity attached directly to a tape or strip 604. The tape or strip 604 may be packaged in accordance with the methods described with reference to FIGS. 6A and/or 6B, or other methods. In some embodiments, the various protective cap devices on the tape or strip 604 can be of different sizes, different antimicrobial compositions, and/or different concentrations of antimicrobial compositions. Other Cover Devices
[050] In some examples, cap devices such as those described herein, as well as in US Patent No. 7,763,006 to Tennican, US Patent No. 7,799,010 to Tennican, and US Patent No. 7,792,322 to Tennican, and/or US Provisional Patent Application No. 61/564,206, filed November 28, 2011 to Tennican et al., all of which are incorporated herein by reference, can be used with syringe devices, such as mixing administration syringes described in US Patent No. 7,635,344 to Tennican et al. , US Patent No. 7,731,678 to Tennican et al., US Patent No. 7,731,679 to Tennican et al., US Patent No. 7,749,189 to Tennican et al., US Patent No. 7,753,891 to Tennican et al. al., US Patent No. 7,776,011 to Tennican et al., US Patent No. 7,985,211 to Tennican et al., US Patent No. 8,002,737 to Tennican, US Patent Application Pub. No. 2007/0167910 filed 11/09/2006 to Tennican et al., US Patent Application Pub. No. 2007/0249996 filed 21/05/2007 Tennican et al, and US Patent Application Pub. No. 2011/0272310 filed on 07/15/2011 to Tennican, which are also incorporated into the addendum by reference.
[051] For example, cap devices may be packaged with a syringe (eg, a mixing administration syringe) in accordance with the methods described in the previous sections, or in other methods of. Cap devices can be packaged in a sterile package along with a syringe in the same compartment as the sterile package or in a compartment separate from the sterile package. Alternatively, one or more cap devices can be packaged separately from the syringe.
[052] In some examples, one or more cap devices may be attached to, over or to the plunger, wings, tip or other portion of the syringe. In that case, the cap devices can be sealed directly to the syringe barrel, or they can be sealed by a separate release liner or cap.
[053] The cap device can be placed over the port access line or IV device after the administrative syringe mixture has been used in the port access line or the IV device and/or an injection or local blood collection.
[054] In some embodiments, a cap device may be used to clean, sanitize and/or disinfect over a surface (eg, skin or tissue) prior to using the administrative syringe mixture. For example, the cap device can be used to clean an injection site before using the administrative syringe mixture at the injection site.
[055] In some embodiments, a cap device may be placed on the mixing administrative syringe to disinfect the syringe prior to use. Additionally, or alternatively, a cap device can be placed on a vial of medication or diluents to disinfect the vial prior to use, between uses and/or during storage. CONCLUSION
[056] Although the application describes modalities with specific structural characteristics and/or methodological acts, it is to be understood that the claims are not necessarily limited to the specific characteristics or acts described. Rather, the specific features and acts are merely illustrative in some embodiments that fall within the scope of the disclosure claims. Rather, the specific features and acts are merely illustrative of some modalities that fall within the scope of the disclosure claims.

权利要求:
Claims (19)
[0001]
1. A medical device, comprising: a first cap (100) releasably coupled to a second cap (102), each cap (100, 102) comprising: a cavity; an exterior surface configured to interface with a user; an inner surface within the cavity; and a foam applicator material (104, 106) attached to the inner surface within the cavity containing a cleaning agent, antiseptic or antimicrobial, CHARACTERIZED by the fact that the cleaning, antiseptic or antimicrobial agent comprises: from 5 mg/ml to 50 mg/ml ethylenediaminetetraacetic acid (EDTA), EDTA acids, EDTA salts, citrate, citrate salts or any combination thereof; 20% to 70% ethanol, by volume; 0.5% to 7.5% hydrogen peroxide, by volume; and water.
[0002]
2. Medical device according to claim 1, CHARACTERIZED by the fact that the foam applicator material (104, 106) comprises a shape similar to a shape of each cavity of each cap (100, 102).
[0003]
3. Medical device according to claim 1, CHARACTERIZED by the fact that the foam applicator material (104, 106) of at least one cap (100, 102) is kept in a state of compression while the first and second caps (100, 102) are coupled and the foam applicator material (104, 106) of at least one cap (100, 102) is configured to extend out of the cavity when the first cap (100) is detached from the second cap ( 102).
[0004]
4. Medical device according to claim 1, CHARACTERIZED by the fact that the foam applicator material (104, 106) comprises a permeable material with different surface treatments, finishes, contours, or combinations thereof.
[0005]
5. Medical device, according to claim 1, CHARACTERIZED by the fact that the first and second caps (100, 102) comprise starch polymer, cellulosic gel, polyurethane, silicone, silicone rubber, polyethylene, polypropylene, elastomer thermoplastic or mixtures thereof.
[0006]
6. Medical device, according to claim 1, CHARACTERIZED by the fact that the first and second covers (100, 102) comprise polypropylene, polyethylene, copolymer material or mixtures thereof.
[0007]
7. Medical device, according to claim 1, CHARACTERIZED by the fact that the first and second caps (100, 102) are coupled by at least one of a thread, a snap-on flange, a snap-on channel. pressure, a molded feature or combination thereof.
[0008]
8. Medical device, according to claim 1, CHARACTERIZED by the fact that the foam applicator material (104) of the first cap (100) comprises a cleaning agent, antiseptic or antimicrobial, different from a cleaning agent, antiseptic or antimicrobial agent on the second cover (102).
[0009]
9. Method, CHARACTERIZED in that it comprises: obtaining a device comprising a first lid (100) releasably coupled to a second lid (102), wherein the first lid (100) and the second lid (102) each comprise one, an interior cavity for storing an applicator and the applicator of at least one of the first cap (100) and second cap (102) comprises a cleaning, antiseptic or antimicrobial agent comprising; from 5 mg/ml to 50 mg/ml ethylenediaminetetraacetic acid (EDTA), EDTA acids, EDTA salts, citrate, citrate salts or any combination thereof; 20% to 70% ethanol, by volume; 0.5% to 7.5% hydrogen peroxide, by volume; and water; removing the first cap (100) from the second cap (102); applying the first cap applicator (100) to a surface; and attaching the second cap (102) to the surface.
[0010]
10. The method of claim 9, CHARACTERIZED by the fact that the applicator of the first cap (100) is configured to extend outside the interior cavity when the first cap (100) is removed from the second cap (102).
[0011]
11. Method according to claim 9, CHARACTERIZED by the fact that the surface is at least one of an intravascular line valve, intravascular line port, or an intravascular line injection site.
[0012]
12. The method according to claim 9, CHARACTERIZED in that removing the first cap (100) from the second cap (102) further comprises at least one of twisting, pulling, snapping or folding the first cap (100) away of the second cover (102).
[0013]
13. Method according to claim 9, CHARACTERIZED by the fact that the second cap applicator (102) further comprises an inner open cell layer configured to store the cleaning agent, antiseptic or antimicrobial, the inner open cell layer connecting two closed cell outer layers at a top and a bottom of the applicator.
[0014]
14. Method according to claim 9, CHARACTERIZED by the fact that the antiseptic or antimicrobial agent is a gel.
[0015]
15. A medical device for protecting a multi-use vial (302) from contamination, comprising: a cap having a cylindrical cavity, the cap having an outer surface configured for interfacing with a user and an inner surface within the cylindrical cavity for interfacing with the bottle (302); a foam insert (304) contained within the cylindrical cavity of the lid, the foam insert (304) having an inner open-cell porous layer between two outer non-porous closed-cell layers; and an infection-inhibiting solution disposed within the inner open-cell porous layer, CHARACTERIZED by the fact that the infection-inhibiting solution comprises: from 5 mg/mL to 50 mg/mL of ethylenediaminetetraacetic acid (EDTA), EDTA acids, salts EDTA, citrates, citrate salts or any combination thereof; 20% to 70% ethanol, by volume; 0.5% to 7.5% hydrogen peroxide, by volume; and water.
[0016]
16. Medical device according to claim 15, CHARACTERIZED by the fact that the inner surface of the cylindrical cavity of the cap comprises one of a tapered stepped surface, a stepped surface, a snap fit flange, internal threads or slots to allow connection from the cap to the multi-use bottle (302).
[0017]
17. Medical device according to claim 15, CHARACTERIZED by the fact that the outer surface of the cover includes a labeling or bar code placement area.
[0018]
18. Medical device according to claim 15, CHARACTERIZED by the fact that at least one of the non-porous outer closed cell layers of the foam has a surface treatment, finish, contour, or combination thereof.
[0019]
19. Medical device according to claim 15, CHARACTERIZED by the fact that the infection-inhibiting solution disposed within the internal open cell porous layer provides a visual indication of contamination when an infectious agent is present on a surface of the vial of multiple use (302).

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CA2863855A1|2013-08-15|

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JP2015509386A|2015-03-30|

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EP2812032A1|2014-12-17|

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JP2015507954A|2015-03-16|

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法律状态:
2018-12-04| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|

2019-12-17| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|

2021-05-18| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|

2021-06-15| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 04/02/2013, OBSERVADAS AS CONDICOES LEGAIS. |

优先权:

申请号 | 申请日 | 专利标题

US201261595635P| true| 2012-02-06|2012-02-06|

US61/595,635|2012-02-06|

US13/757,465|US9192443B2|2012-02-06|2013-02-01|Combined cap applicators|

US13/757,465|2013-02-01|

PCT/US2013/024651|WO2013119509A1|2012-02-06|2013-02-04|Combined cap applicators|

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